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however, senolytics are uncommon and their underlying mechanisms remain largely unknown

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Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively

Journal of Investigative Dermatology, 125(5), 101-105

Through SA--gal staining, we found that FOXO4-DRI also reduced the number of positive cells in the aorta of D-galactose induced aged mice (Figure 2C)